Aging

A circadian secret to a long life

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Science  11 Dec 2015:
Vol. 350, Issue 6266, pp. 1328-1329
DOI: 10.1126/science.350.6266.1328-d

Dietary restriction (reduced nutrient intake without malnutrition) increases life span in multiple species, including fruit flies, but how this occurs is largely unknown. Katewa et al. now find that in flies, changes in the expression of genes that regulate the circadian clock underlie the life-extending effect of dietary restriction. Dietary restriction increased the amplitude of daily cycles of clock gene expression in tissues such as the fly head and body. In flies with mutated clock genes, dietary restriction failed to increase longevity. Moreover, genetically increasing the periodicity of circadian gene expression also extended the life span of flies. Further analysis indicated that circadian gene expression contributes to changes in metabolism that mediate the effects of dietary restriction on life span.

Cell Metab. 10.1016/j.cmet.2015.10.014 (2015)

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