PerspectiveCell Signaling

Seeing mTORC1 specificity

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Science  01 Jan 2016:
Vol. 351, Issue 6268, pp. 25-26
DOI: 10.1126/science.aad9696

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Cells must sense their environment to determine whether conditions are suitable for growth. Despite the physiological importance of a multiprotein complex called mammalian/mechanistic target of rapamycin complex 1 (mTORC1) in this process, a detailed molecular understanding of its assemblage and regulation of its serine-threonine kinase function have proven difficult to elucidate. On page 48 of this issue, Aylett et al. (1) help uncover the molecular underpinnings of mTORC1, while on pages 43 and 53, Wolfson et al. (2) and Saxton et al. (3), respectively, make strides in determining how mTORC1 is regulated by the amino acid leucine.