The Drp, Drp, Drp of mitochondrial fission

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Science  01 Jan 2016:
Vol. 351, Issue 6268, pp. 38-39
DOI: 10.1126/science.351.6268.38-c

Mitochondria are very dynamic organelles and undergo regular fusion and fission reactions. Fission involves the dynamin GTPase Drp1, a cytosolic enzyme that is recruited to mitochondria, where it oligomerizes and contracts to cause the mitochondrial membrane to constrict. Ji et al. studied Drp1 dynamics in live cells. Contrary to current models, fission sites did not directly recruit Drp1 from the cytoplasm. Instead, mitochondria progressively added Drp1 molecules to form oligomers. Most mature Drp1 oligomers did not mediate fission. When the authors experimentally induced mitochondrial fission, actin and Drp1 accumulated sequentially at specific mitochondrial fission sites. Thus, the assembly of fission-productive Drp1 oligomers involves recruitment, maturation, and actin-dependent conversion.

eLife 10.7554/eLife.11553 (2015).

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