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Science  01 Jan 2016:
Vol. 351, Issue 6268, pp. 8-9
DOI: 10.1126/science.351.6268.8

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At the end of 2015, Science looked back at some of the biggest science stories of the year. Now we're looking forward, pondering which research trends and ideas are poised to create buzz in 2016—making them the scientific equivalent of the recent Star Wars movie—and which ones are losing some steam. From the rise of reusable rockets to sequencing entire ancient genomes to the rapidly spreading Zika virus to the hunt for a sidekick to the Higgs boson, we offer our best guesses—in no particular order—of the new themes that we think will take hold in 2016, shoving aside some once-sizzling topics.