Immunogenomics

Following the bloodline downstream

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Science  08 Jan 2016:
Vol. 351, Issue 6269, pp. 135-136
DOI: 10.1126/science.351.6269.135-b

Seven progenitor cells lead to a variety of blood cells

PHOTO: ANDREW SYRED/SCIENCE SOURCE

There are many different types of blood cells that originate from a single progenitor cell, but their developmental pathways are not well understood. Applying single-cell sequencing to mouse bone marrow cell populations, Paul et al. identify seven myeloid progenitor states indicating developmental heterogeneity among these cells. Characterizing cellular in vivo functions, they find clusters of cells that express previously well-characterized transcriptional profiles in both rare and common cell types, as well as novel profiles helping demarcate different cellular lineages.

Cell 163, 1663 (2015).

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