DNA Repair

Breaking DNA for gene expression

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Science  08 Jan 2016:
Vol. 351, Issue 6269, pp. 135-136
DOI: 10.1126/science.351.6269.135-d

DNA breaks are potentially highly mutagenic, and the cell has an array of DNA damage response systems to rapidly repair such damage. Curiously, DNA repair factors have been found associated with transcriptionally paused, inducible genes. Bunch et al. show that the activation of paused and inducible genes in human tissue culture cells triggers DNA breaks at the RNA polymerase pause site. The subsequent recruitment and signaling activity of DNA repair factors is critical for DNA repair, release of the RNA polymerase, and the transition to the transcription elongation phase of gene expression.

Nat. Commun. 6, 10191 (2015).

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