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Transcription factors LRF and BCL11A independently repress expression of fetal hemoglobin

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Science  15 Jan 2016:
Vol. 351, Issue 6270, pp. 285-289
DOI: 10.1126/science.aad3312

Article Information

vol. 351 no. 6270 285-289

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Print ISSN: 
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History: 
  • Received for publication August 28, 2015
  • Accepted for publication December 7, 2015

Author Information

  1. Takeshi Masuda1,
  2. Xin Wang2,
  3. Manami Maeda1,
  4. Matthew C. Canver3,
  5. Falak Sher3,
  6. Alister P. W. Funnell4,
  7. Chris Fisher5,
  8. Maria Suciu5,
  9. Gabriella E. Martyn4,
  10. Laura J. Norton4,
  11. Catherine Zhu1,
  12. Ryo Kurita6,
  13. Yukio Nakamura6,7,
  14. Jian Xu3,8,
  15. Douglas R. Higgs5,
  16. Merlin Crossley4,
  17. Daniel E. Bauer3,
  18. Stuart H. Orkin3,9,
  19. Peter V. Kharchenko2,*,
  20. Takahiro Maeda1,*
  1. 1Division of Hematology, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
  2. 2Department of Biomedical Informatics, Harvard Medical School, Boston, MA 02115, USA.
  3. 3Division of Hematology/Oncology, Boston Children’s Hospital, Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Stem Cell Institute, Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA.
  4. 4School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia.
  5. 5Medical Research Council, Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, Oxford University, Oxford, UK.
  6. 6Cell Engineering Division, RIKEN BioResource Center, Tsukuba, Ibaraki, Japan.
  7. 7Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan.
  8. 8Children’s Research Institute, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
  9. 9Howard Hughes Medical Institute, Boston, MA 02115, USA.
  1. *Corresponding author. E-mail: peter.kharchenko{at}post.harvard.edu (P.V.K.); tmaeda{at}partners.org (T.M.)

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