Science Webinar Series

Part 5: Targeting Cancer Pathways: Understanding Immune Checkpoints

Science  15 Jan 2016:
Vol. 351, Issue 6270, pp. 303
DOI: 10.1126/science.351.6270.303-b

Summary

This webinar is the fifth in a series focusing on the cancer pathways that support tumor development, the emerging research in identifying and targeting these pathways, and innovations in the development of increasingly effective cancer therapy options. Recent advances in our understanding of cancer have revealed that the disease cannot be understood through simple analysis of genetic mutations within cancerous cells. Instead, tumors should be considered as complex tissues in which the cancer cells communicate directly and indirectly with the surrounding cellular microenvironment and evolve traits that promote their own survival. In this webinar, we will explore how tumors exploit immune modulatory mechanisms to generate and thrive in their own immunosuppressive microenvironment. Further, we will examine how these mechanisms can be targeted to develop better therapeutic options.