Cancer Metastasis

Suppressing cancer spread

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Science  22 Jan 2016:
Vol. 351, Issue 6271, pp. 351-352
DOI: 10.1126/science.351.6271.351-g

Preventing cancer metastasis is a major challenge, but the discovery of potential new metastasis suppressor genes may help guide new therapies. Ozturk et al. now show that relative to nonmetastatic cells, metastatic breast cancer cell lines express lower amounts of the protein serum deprivation response (SDPR). When the authors overexpressed SDPR in metastatic breast cancer cells, the cells migrated poorly in culture, and when injected into mice, they showed a reduced ability to disseminate to the lung. Analysis of gene expression data sets indicated a loss of SDPR in multiple tumor types. The gene encoding SDPR appears to be silenced by an epigenetic mechanism: DNA methylation of its promoter.

Proc. Natl. Acad. Sci. U.S.A. 10.1073/pnas.1514663113 (2016).

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