Prescription drugs obscure microbiome analyses

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Science  29 Jan 2016:
Vol. 351, Issue 6272, pp. 452-453
DOI: 10.1126/science.aaf1353

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Although observations linking members of the gut microbiome to human disease have been plentiful, some are fraught with complex and confounding variables, emphasizing the need for vetting such associations with greater computational and mechanistic rigor. A recent study by Forslund et al. (1) adds another dimension for consideration by illustrating how medications may adversely affect the microbiome—an interaction often overlooked in post hoc analyses of disease-microbe relationships.