Cell Migration

Dendritic cells have two ways to tango

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Science  29 Jan 2016:
Vol. 351, Issue 6272, pp. 462-463
DOI: 10.1126/science.351.6272.462-f

The activation status of dendritic cells determines how they migrate

PHOTO: DENNIS KUNKEL MICROSCOPY, INC./VISUALS UNLIMITED, INC.

Immature dendritic cells reside in peripheral tissues and use their high migratory capacities to sniff out danger-associated antigens; when they encounter antigens, dendritic cells mature and rapidly migrate to lymph nodes to initiate the adaptive immune response. Vargas et al. show that a switch in actin nucleating machineries adapts the dendritic cell migration mode. Arp2/3 nucleates actin at the front of immature dendritic cells, and dendritic cells require it for antigen uptake, but Arp2/3 reduces cell speed and persistence. Mature dendritic cell rely on the formin mDia1 to migrate. mDia1 changes locomotion from diffusive migration to a persistent random walk. This transition helps mature dendritic cells to move along chemokine gradients toward the lymph nodes.

Nat. Cell Biol. 18, 43 (2016).

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