Cell Division

An open and closed case

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Science  19 Feb 2016:
Vol. 351, Issue 6275, pp. 828-829
DOI: 10.1126/science.351.6275.828-c

One of the first recognized stages of an animal cell's entry into mitosis is the breakdown of the nuclear envelope (NE), a double-membraned structure that contains a cell's chromosomes. However, certain yeasts, including the lab workhorse Saccharomyces cerevisiae, keep their NE intact throughout mitosis; so-called closed mitosis. Makarova et al. studied two yeasts, one of which, Schizosaccharomyces japonicus, performs open mitosis, breaking down its NE during chromosome partitioning; and one of which, S. pombe, performs closed mitosis. They found that S. pombe–like mitotic regulation of a single lipid-modifying enzyme allowed S. japonicus to expand its NE and thus perform closed mitosis.

Curr. Biol. 26, 237 (2016)

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