You are currently viewing the summary.
View Full TextLog in to view the full text
AAAS login provides access to Science for AAAS members, and access to other journals in the Science family to users who have purchased individual subscriptions.
More options
Download and print this article for your personal scholarly, research, and educational use.
Buy a single issue of Science for just $15 USD.
Summary
Asymmetric synthesis, reactions that produce a high proportion of one enantiomer of a chiral compound relatively to the other, are of ever-growing importance, particularly for creating pure pharmaceuticals. Asymmetric catalysis (1) uses a recyclable or regenerated chiral molecule to perform these reactions, but achieving high yields can be challenging if the substrate is relatively unreactive. On page 949 of this issue, Gatzenmeier et al. (2) report a highly efficient method that relies on an in situ–generated catalyst to produce complex structures in excellent yields of almost pure enantiomers from low-reactivity starting materials.
