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Synchronous Drosophila circadian pacemakers display nonsynchronous Ca2+ rhythms in vivo

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Science  26 Feb 2016:
Vol. 351, Issue 6276, pp. 976-981
DOI: 10.1126/science.aad3997

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Layered versatility atop circadian clocks

The circadian clock evolved to allow cells or organisms to anticipate changes in physiological requirements associated with Earth's 24-hour light/dark cycle. Some activities, however, need to occur out of phase with the core clock. Liang et al. imaged changes in intracellular concentration of Ca2+ in populations of neurons in the fruit fly brain. Although the underlying clock was synchronous, the rhythms of Ca2+ changes corresponded with distinct timing of activities associated with activity of the particular neuronal populations. Proper coordination of these distinct phases required expression of the neuropeptide pigment-dispersing factor and its receptor.

Science, this issue p. 976