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Science  26 Feb 2016:
Vol. 351, Issue 6276, pp. 985
DOI: 10.1126/science.351.6276.985

Microscope Tools

Taking well-plate imaging to the next level, Olympus presents two innovative tools for the customizable IX3 inverted microscopes. The new IX3-ZDC2 module offers cutting-edge focal drift compensation technology, enabling accurate focus stability during long time-lapse experiments. Complementing this is the latest cellSens version 1.14 software, which features an improved Well Navigator tool for smart and flexible multiwell experimental setup. Combined, these updates form a highly accurate, reliable, and easy-to-use well-plate imaging system for live-cell imaging. Compensating for changes such as thermal drift, Z-drift compensation (ZDC) technology employs an infrared laser diode to measure focus distance. The new IX3-ZDC2 is able to focus up to four times faster than the previous model, and includes a fully motorized dichroic mirror movement. The Well Navigator makes it possible to move to a specific well with one click and simplifies management of different imaging parameters in individual wells or groups of wells.

HLA Analysis Software

The Axiom HLA Analysis software is designed for automated, high-resolution human leukocyte antigen (HLA) typing from any genotyping dataset containing coverage of the extended major histocompatibility complex (MHC) region. The software's unique imputation algorithm enables four-digit HLA typing from genome-wide association studies (GWAS), combining genotyping and high-resolution HLA typing into a single assay. Prior to the availability of Axiom HLA Analysis, researchers conducted separate HLA molecular testing of their samples or used complex analysis workflows to generate HLA types from genotype data. The algorithms incorporated into the software provide simple, "push-button" analysis to dramatically decrease researchers' cost and workload. The Axiom HLA Analysis software can be used with data from a number of Affymetrix array products, including the new Axiom Transplant Genotyping Array and UK Biobank Axiom Array, as well as the Genome-Wide Human SNP Array 6.0. Genotyping data produced by other manufacturers' systems can be economically HLA-typed by Affymetrix Research Service Laboratory using the new software.

Tissue Analysis Software

Tissue Studio 4.1 features powerful machine learning and the ability to automate routine image analysis tasks, enabling researchers to develop a customized image analysis solution in as little as 20 minutes, and to reduce preclinical safety and toxicity study lengths from weeks to just days. It offers scientists an out-of-the-box solution that provides comprehensive and consistent data from any tissue-based assay, and can handle complex tasks such as biological heterogeneity and staining variation. Tissue Studio 4.1's image analysis allows researchers to automate tedious manual analysis, produces quantitative readouts that can be mined and correlated, and simplifies analysis tasks and workflows. Adding to these standard benefits, Tissue Studio uniquely overcomes inherent biological and staining variability to accurately detect regions of interest and distinguish cell types and subtypes within target regions across any number of tissue slides. Tissue Studio 4.1 brings powerful speed and efficiency improvements to the solution of choice for image analysis.

Imaging Software

The ZEN 2 core imaging software is easy to use and simply designed. It allows users to achieve the highest quality results together with established ZEISS hardware. ZEN 2 core gives users the benefit of an adaptive user interface suited specifically to industrial and research applications. The easy graphical user interface (GUI) configuration fits tasks of all kinds and of any complexity. Users can adapt the GUI to their workflows to simplify their work. ZEISS ZEN 2 core also offers configurable user management, adjusting the software to different users and user levels. Given the ZEN 2 core's straightforward workflows, users can count on fast, reproducible analysis and measurement results. Its ability to create job templates ensures users get comparable results every time. ZEISS ZEN 2 core offers an interface to many other software platforms and hardware accessories.

Gene Editing Software

Developed in collaboration with Desktop Genetics, gUIDEbook bioinformatics software has been designed to support researchers working with clustered regularly interspaced short palindromic repeats (CRISPR) genome editing. Successful CRISPR genome editing relies on the quality of the guide RNA (gRNA) design, determined by bioinformatics software. The gUIDEbook software has been developed to provide the most complete solution available for designing CRISPR genome editing experiments. The platform enables researchers to generate knockouts, knockins, mutations, or tags through powerful, laboratory-validated DNA search algorithms behind a simple and intuitive user interface. Utilizing state-of-the-art scoring functions, gUIDEbook allows an entire gene to be quickly reviewed for the best guide or guides for both wild-type and CRISPR-associated 9 protein (Cas9) "nickase" experiments. The current version of gUIDEbook supports human and mouse genomes with additional genomes to be added later, and offers two levels of use depending on experimental requirements and the level of user experience. Once researchers have selected the best guides for an experiment, they can then easily order their chosen guides.

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