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Science  04 Mar 2016:
Vol. 351, Issue 6277, pp. 1101
DOI: 10.1126/science.351.6277.1101

Pathology Imaging System

The Vectra 3 is an automated, high-throughput quantitative pathology imaging system. The system's new seven-color multiplexing and visualization capabilities are designed to enable pathologists and oncologists conducting research to gain a deeper level of understanding of disease mechanisms related to new cancer immunotherapy approaches. The system visualizes, analyzes, quantifies, and phenotypes immune cells in situ in formalin-fixed paraffin-embedded (FFPE) tissue sections. It incorporates 10x whole slide imaging and the Phenochart whole slide viewer, allowing researchers to annotate and navigate slides with interactive interfaces to better identify regions of interest for detailed multispectral acquisition. The multiplexing capability enables identification and quantification of multiple biomarkers and reveals spatial context within a digital workflow to assist researchers with better, faster decisions. Combined with PerkinElmer's inForm image analysis software, which automatically identifies and quantifies cell populations in tissue, the Vectra 3 system provides researchers the power of multiplexed biomarker imaging and quantitative analysis within a familiar digital workflow.

Stem Cell Counting Technology

Since the beginnings of mammalian tissue stem cell biology, counting has been the bane of both basic research and clinical stem cell studies. Biomarkers, such as CD34 and CD133, do not identify tissue stem cells with sufficient specificity for counting them. Asymmetrex's AlphaSTEM technology, developed with AlphaSTAR Corporation, provides precise determinations of the number, viability, and self-renewal pattern (asymmetric versus symmetric) of stem cells in complex tissue cell preparations, including both research and medical specimens. AlphaSTEM technology uses computer simulation to extract tissue stem cell properties from specially prescribed serial culture data. The AlphaSTEM tissue stem cell counting technology has many exciting applications, including determining the number of stem cells in experimental samples, determining the stem cell dose for transplantation treatments, identifying agents that can improve the vitality of transplanted tissue stem cells, and identifying agents that are toxic to tissue stem cells.

Cancer Stem Cell Identification Kit

The new AldeRed ALDH Detection Kit is designed for identifying and isolating cancer stem cells. The AldeRed reagent is used to label cancer stem cells with a red fluorescent dye, making it possible to distinguish cancer stem cells in live cell populations where specific identification was previously impossible. Aldehyde dehydrogenase (ALDH), a cancer stem cell marker enzyme, causes the AldeRed reagent to fluoresce in the far-red spectrum, allowing the cancer cells to be identified and isolated with concurrent use of green fluorescent cell lines, transgenic animals, and reporter assays. Previous ALDH reporters exhibited green fluorescence, which made it difficult to identify positive cells in an otherwise green fluorescent background.

Monoclonal Antibody

A new immunohistochemistry (IHC)-approved, human-specific, VISTA rabbit monoclonal antibody (mAb) is now available for use in biomedical research. VISTA (V-domain Ig suppressor of T-cell activation, C10orf54, GI24, SISP1) is a negative checkpoint control protein that regulates T-cell activation and immune response. Its role in negative checkpoint control has made it an important target in the field of tumor immunology, a field that seeks to develop better therapeutic options by dismantling the mechanisms tumors use to generate and thrive in their own immunosuppressive microenvironments. VISTA (D1L2G) XP Rabbit mAb #64953 is validated using Cell Signaling Technology's rigorous standards, to recognize human VISTA in IHC and Western blot research applications.

ChIP-Validated Antibodies

A new range of chromatin immunoprecipitation (ChIP)-validated antibodies are now available. The use of high-quality and specific ChIP-validated antibodies is essential for the success of a ChIP assay. The antibody must recognize and bind to native protein that is bound to DNA. Antibodies from other applications do not always work well in ChIP. These top-quality validated antibodies will give our customers confidence in their protocols and their results, safe in the knowledge that a ChIP-validated antibody was at the heart of their assay. Chromatrap currently offers a range of ChIP kits for quantitative polymerase chain reaction (qPCR) or sequencing and has now launched the first nine antibodies in its validated antibody program, which are H3, RNA pol II (S), RNA pol II (S5), H3K9me3, 5mC, AcH3, AcH4, AR, and Sin3a. Chromatrap validated antibodies are available in 100-uL aliquots at a concentration of 1 mg/ml, delivered overnight.

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