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Science  11 Mar 2016:
Vol. 351, Issue 6278, pp. 1223
DOI: 10.1126/science.351.6278.1223-a

Transplant Genotyping Array

The Axiom Transplant Genotyping Array has been designed to improve transplantation success and individualize donor/patient selection and treatment. The array comprises ~780,000 markers, including over 30,000 variants that may contribute to transplant rejection or other complications. Researchers will also find the array useful in the study of immunology and drug treatments for disease; meta-analyses may be conducted combining data with other genotype databases such as the UK Biobank cohort, a collection of more than 500,000 volunteers genotyped using the Affymetrix UK Biobank Axiom Array. Research with this new transplant array focuses on finding transplant-related variants that will provide insight into early detection of graft-versus-host disease as well as genomic markers associated with the metabolism of immunosuppressant drugs. In addition, Affymetrix Axiom HLA Analysis software enables affordable, high-throughput, accurate analysis of 11 classical loci at four-digit resolution by imputing human leukocyte antigen (HLA) type from Axiom array-generated genotype data.

Inflammation Panels

To understand the role that inflammation plays in diseases such as cancer, heart disease, and diabetes, researchers must understand the complex interplay of many inflammatory proteins. With the Bio-Plex Pro Human Inflammation Panels, complex immune responses can be profiled in a single assay for the first time. The kits detect and quantify key inflammation biomarkers from the tumor necrosis factor (TNF), type 1 and 2 interferon (IFN), matrix metalloproteinase (MMP), and interleukin-10 (IL-10)/regulatory T cell (Treg) cytokine families. By studying up to 37 inflammatory proteins in one assay, researchers save time and money and increase sample throughput. Results can be generated in as little as three to four hours. Premixed, ready-to-use screening kits are available in 37-plex and 24-plex formats. Additionally, a Treg pathway-focused 12-plex assay kit is available. Researchers also have the added flexibility of ordering singleplex or custom kits for more focused investigations.

Stem Cell Counting Technology

Since the beginnings of mammalian tissue stem cell biology, counting has been the bane of both basic research and clinical stem cell studies. Biomarkers, such as CD34 and CD133, do not identify tissue stem cells with sufficient specificity for counting them. Asymmetrex's AlphaSTEM technology, developed with AlphaSTAR Corporation, provides precise determinations of the number, viability, and self-renewal pattern (asymmetric versus symmetric) of stem cells in complex tissue cell preparations, including both research and medical specimens. AlphaSTEM technology uses computer simulation to extract tissue stem cell properties from specially prescribed serial culture data. The AlphaSTEM tissue stem cell counting technology has many exciting applications, including determining the number of stem cells in experimental samples, determining the stem cell dose for transplantation treatments, identifying agents that can improve the vitality of transplanted tissue stem cells, and identifying agents that are toxic to tissue stem cells.

GC Column

The Zebron ZB-5MSPLUS is a highly inert 5% phenyl-arylene phase gas chromatography (GC) column for challenging separations. Designed with rigorous fused-silica deactivation and quality control processes, the ZB-5MSPLUSvirtually eliminates active sites on the column's surface that can negatively affect peak shapes for challenging compounds. Most GC chromatographers are accustomed to using a 5% phenyl-arylene phase, and many work with active compounds. These researchers can switch to the new inert column for higher responses and lower detection limits without redeveloping their methods. The ZB-5MSPLUS produces better peak shapes without retention time shifts and ultimately increases a lab's productivity. GC chromatographers will often use a thicker-film column to compensate for active compounds' proclivity to stick to the column surface. The new deactivated column reduces the need to compensate for this activity. The ZB-5MSPLUS features completely redesigned packaging using both recycled and recyclable materials and is easier to open and store.

Analytical Column

The second generation CIMac r-Protein A Analytical Column is a short-bed, high-performance monolithic column primarily intended for fast, efficient, and reproducible qualitative and quantitative analyses of immunoglobulin G (IgG). It is suitable for use with high performance liquid chromatography (HPLC) and ultra-performance liquid chromatography (UPLC) systems. Quantification of IgG is possible between 0.20 µg and 20 µg. Its small volume and short column length allow operation at high volumetric flow rates (up to 3 mL/min). The information about product quantity and purity is thus generated in just 1 minute. The column has innovative symmetric design for bidirectional flow, also extending column lifetime. The CIMac r-Protein A is therefore the chromatographic tool of choice for in-process (process analytical technology) and final control of IgG purified from cell culture supernatant or human plasma.

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