A satiating signal

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Science  18 Mar 2016:
Vol. 351, Issue 6279, pp. 1268-1269
DOI: 10.1126/science.aaf5216

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The worldwide human obesity epidemic has provoked a great deal of experimentation to understand the biological controls of energy expenditure and food intake, two processes that together determine energy balance. Because food intake relies on feeding behavior that is determined by the brain, studies have focused on how the central nervous system receives and behaviorally responds to signals of metabolic status. On page 1293 of this issue, Lagerlöf et al. (1) report that a glycosylation enzyme serves as a neuronal nutrient sensor that is critical in the control of food intake and body weight.