Feeding Behavior

When enough isn't enough

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Science  18 Mar 2016:
Vol. 351, Issue 6279, pp. 1276
DOI: 10.1126/science.351.6279.1276-a

Mice lacking OGT in certain neurons become obese


Overeating and obesity are rapidly becoming worldwide problems. Normally, mice do not overeat—they balance their caloric intake with their caloric needs. Lagerlöf et al. deleted an enzyme called O-GlcNAc transferase (OGT) from a subset of neurons in the mouse hypothalamus (see the Perspective by Schwartz). After the loss of OGT, the animals began to overeat and rapidly gained weight. The animals ate more at meal times, rather than eating more often. Thus, OGT seems to regulate satiety and helps to couple caloric intake to caloric need.

Science, this issue p. 1293; see also p. 1268

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