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Structural and molecular basis for Ebola virus neutralization by protective human antibodies

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Science  18 Mar 2016:
Vol. 351, Issue 6279, pp. 1343-1346
DOI: 10.1126/science.aad6117

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vol. 351 no. 6279 1343-1346

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History: 
  • Received for publication October 18, 2015
  • Accepted for publication February 17, 2016

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Author Information

  1. John Misasi1,5,8,*,
  2. Morgan S. A. Gilman2,*,
  3. Masaru Kanekiyo1,*,
  4. Miao Gui4,*,
  5. Alberto Cagigi1,
  6. Sabue Mulangu1,
  7. Davide Corti6,
  8. Julie E. Ledgerwood1,
  9. Antonio Lanzavecchia6,9,
  10. James Cunningham5,
  11. Jean Jacques Muyembe-Tamfun7,
  12. Ulrich Baxa3,
  13. Barney S. Graham1,
  14. Ye Xiang4,,,
  15. Nancy J. Sullivan1,,,
  16. Jason S. McLellan2,
  1. 1Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
  2. 2Department of Biochemistry, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USA.
  3. 3Electron Microscopy Laboratory, Cancer Research Technology Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.
  4. 4Centre for Infectious Diseases Research, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Beijing Advanced Innovation Center for Structural Biology, Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing 100084 China.
  5. 5Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
  6. 6Institute for Research in Biomedicine, Università della Svizzera Italiana, CH-6500 Bellinzona, Switzerland.
  7. 7National Institute for Biomedical Research, National Laboratory of Public Health, Kinshasa B.P. 1197, Democratic Republic of the Congo.
  8. 8Division of Infectious Diseases, Boston Children’s Hospital, Boston, MA 02215, USA.
  9. 9Institute of Microbiology, ETH Zurich, CH-8093 Zurich, Switzerland.
  1. Corresponding author. E-mail: njsull{at}mail.nih.gov (N.J.S.); yxiang{at}mail.tsinghua.edu.cn (Y.X.)
  1. * These authors contributed equally to this work.

  2. These authors contributed equally to this work.

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