Report
Structural and molecular basis for Ebola virus neutralization by protective human antibodies
- John Misasi1,5,8,*,
- Morgan S. A. Gilman2,*,
- Masaru Kanekiyo1,*,
- Miao Gui4,*,
- Alberto Cagigi1,
- Sabue Mulangu1,
- Davide Corti6,
- Julie E. Ledgerwood1,
- Antonio Lanzavecchia6,9,
- James Cunningham5,
- Jean Jacques Muyembe-Tamfun7,
- Ulrich Baxa3,
- Barney S. Graham1,
- Ye Xiang4,†,‡,
- Nancy J. Sullivan1,†,‡,
- Jason S. McLellan2,†
- 1Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
- 2Department of Biochemistry, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USA.
- 3Electron Microscopy Laboratory, Cancer Research Technology Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.
- 4Centre for Infectious Diseases Research, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Beijing Advanced Innovation Center for Structural Biology, Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing 100084 China.
- 5Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
- 6Institute for Research in Biomedicine, Università della Svizzera Italiana, CH-6500 Bellinzona, Switzerland.
- 7National Institute for Biomedical Research, National Laboratory of Public Health, Kinshasa B.P. 1197, Democratic Republic of the Congo.
- 8Division of Infectious Diseases, Boston Children’s Hospital, Boston, MA 02215, USA.
- 9Institute of Microbiology, ETH Zurich, CH-8093 Zurich, Switzerland.
- ↵‡Corresponding author. E-mail: njsull{at}mail.nih.gov (N.J.S.); yxiang{at}mail.tsinghua.edu.cn (Y.X.)
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Science 18 Mar 2016:
Vol. 351, Issue 6279, pp. 1343-1346
DOI: 10.1126/science.aad6117
Vol. 351, Issue 6279, pp. 1343-1346
DOI: 10.1126/science.aad6117
John Misasi
Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.Division of Infectious Diseases, Boston Children’s Hospital, Boston, MA 02215, USA.
Morgan S. A. Gilman
Department of Biochemistry, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USA.
Masaru Kanekiyo
Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Miao Gui
Centre for Infectious Diseases Research, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Beijing Advanced Innovation Center for Structural Biology, Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing 100084 China.
Alberto Cagigi
Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Sabue Mulangu
Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Davide Corti
Institute for Research in Biomedicine, Università della Svizzera Italiana, CH-6500 Bellinzona, Switzerland.
Julie E. Ledgerwood
Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Antonio Lanzavecchia
Institute for Research in Biomedicine, Università della Svizzera Italiana, CH-6500 Bellinzona, Switzerland.Institute of Microbiology, ETH Zurich, CH-8093 Zurich, Switzerland.
James Cunningham
Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
Jean Jacques Muyembe-Tamfun
National Institute for Biomedical Research, National Laboratory of Public Health, Kinshasa B.P. 1197, Democratic Republic of the Congo.
Ulrich Baxa
Electron Microscopy Laboratory, Cancer Research Technology Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.
Barney S. Graham
Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Ye Xiang
Centre for Infectious Diseases Research, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Beijing Advanced Innovation Center for Structural Biology, Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing 100084 China.
Nancy J. Sullivan
Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Jason S. McLellan
Department of Biochemistry, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USA.
