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Science  18 Mar 2016:
Vol. 351, Issue 6279, pp. 1347
DOI: 10.1126/science.351.6279.1347

Microplate Reader

The new reference multimode high-throughput screening (HTS) reader PHERAstar FSX is the latest evolution in microplate reader instrumentation and combines high sensitivity, speed, and unmatched flexibility in plate formats up to 3,456 wells. Built on the successful PHERAstar FS platform, the PHERAstar FSX has improved features that make it superior to any microplate reader on the market. The PHERAstar FSX offers all the leading nonisotopic detection technologies and is unmatched in sensitivity and speed in fluorescence intensity (FI) and fluorescence polarization (FP). Moreover, the reader offers an ultrahigh dynamic range in luminescence, enabling greater flexibility and more precise measurement results. The outstanding sensitivity of the PHERAstar FSX is based on an innovative optical design including three independent light sources. To ensure best performance for any assay, the PHERAstar FSX comes with the next-generation laser for time-resolved fluorescence/time-resolved fluorescence energy transfer (TRF/TR-FRET).

Antibodies

Bio-Rad has expanded its new product line of Western blot-validated PrecisionAb Antibodies to include a vast collection of cancer targets (e.g., Bcl2, Bax, p53). These targets play central roles in the switch that turns a normal cell into a tumor cell. As part of the PrecisionAb line of primary antibodies, the new offerings have been validated against 12 biologically relevant cell lines that express endogenous levels of the targets. Only antibodies that detect these proteins with high sensitivity and specificity are included in the PrecisionAb product line. The high specificity prevents misidentification of proteins and helps detect proteins that are downregulated in cancer. The antibodies are sold in trial sizes to allow for economical in-house validation and a positive control lysate so researchers can benchmark the target molecular weight.

UV-Vis Spectrophotometer

The NanoDrop One and NanoDrop One° UV-Vis microvolume spectrophotometers are designed to help life science researchers gain a more complete understanding of sample quality and avoid costly delays due to troubleshooting and repeating experiments. These new spectrophotometers introduce Acclaro sample intelligence technology, which enables researchers to identify sample contaminants and obtain corrected concentration results, receive instant feedback about sample quality with on-demand technical support and guided troubleshooting, and confidently measure samples with embedded sensor and digital image analysis. The NanoDrop One's high-resolution, touchscreen interface makes it easy to use as a compact, ergonomic instrument, while the powerful auto-range pathlength technology facilitates accurate measurements for concentrated samples with no need for dilutions. The NanoDrop sample-retention system measures 1–2 μL of sample in seconds without the need for cuvettes, making it a cost- and time-effective solution for busy labs. The NanoDrop One° instrument features both pedestal and cuvette measuring positions.

Western Blot Substrate

Chemi FP is the most sensitive horseradish peroxidase (HRP) substrate for Western blotting yet, with attomole sensitivity and a long-lasting signal output. The light emission is stable for 10 times longer than is possible with typical enhanced chemiluminescence (ECL) substrates. This enables the user to detect bands not usually visualized with other commonly used substrates. Importantly, the high signal-to-noise level and large dynamic range of the product makes it ideal for quantifying low-intensity bands. The chemifluorescence emission allows the Chemi FP to be imaged using chemifluorescence imaging techniques in addition to traditional charge-coupled device (CCD) imaging systems and film. Chemi FP is the perfect substrate to use when working with one of the Omega Lum Gel Documentation systems. The combination of one of Aplegen's three Western blotting applications with the Chemi FP guarantees superb results.

Mass Detector

The new control driver for the Microsaic 4000 MiD mass detector expands the portfolio of instruments managed by Clarity, a single-point control software platform. The Microsaic 4000 MiD control module includes both digital control and data acquisition for the detector. It includes MiDas compact interface module controls and allows performing detector calibration, maintenance, and service operations from the Device Monitor software window. Clarity Chromatography Software provides seamless integration of Microsaic 4000 MiD with a wide range of high-performance liquid chromatography (HPLC) systems that are already controlled by Clarity. Clarity MS Extension greatly extends Clarity capabilities. Clarity is able to evaluate spectral data from mass spectrometry (MS) detectors together with data from conventional HPLC detectors (including quantification) and add the third dimension for data analysis. Clarity Chromatography Software has a strong position in the chromatography data systems market. Clarity is highly regarded for its intuitive approach, excellent performance, cost effectiveness, and proficient technical support.

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  • Newly offered instrumentation, apparatus, and laboratory materials of interest to researchers in all disciplines in academic, industrial, and governmental organizations are featured in this space. Emphasis is given to purpose, chief characteristics, and availabilty of products and materials. Endorsement by Science or AAAS of any products or materials mentioned is not implied. Additional information may be obtained from the manufacturer or supplier.

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