Engineering open structures using DNA

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Science  25 Mar 2016:
Vol. 351, Issue 6280, pp. 1412-1413
DOI: 10.1126/science.351.6280.1412-g

In DNA origami, designed libraries of single strands assemble into complex structure in two and three dimensions. However, these tend to be block or solid structures, which is often an inefficient use of material. In the engineering world, structures based on triangles allow for open frames or hollow structures that still show strong resistance to shearing forces. Matthies et al. developed a program to search for continuous, flat, triangular structures, which were used as the inputs for the DNA sequence design program. With the addition of connector strands, the flat structures become three-dimensional, with tetrahedral, octahedral, or irregular dodecahedral trusses.

Nano Lett. 10.1021/acs.nanolett.6b00381 (2016).

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