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Science  25 Mar 2016:
Vol. 351, Issue 6280, pp. 1479
DOI: 10.1126/science.351.6280.1479

Thermal Cycler

The new qTOWER³ real-time polymerase chain reaction (PCR) thermal cycler is a patented fiber-optic shuttle system with a unique light source powered by four high-performance light-emitting diodes (LEDs), which guarantees ideal excitation and detection of known fluorescent dyes up to the dark red. In addition, the system's highly sensitive detection module can be equipped with up to six different color modules. Color modules are upgradeable, allowing the system to benefit from future developments. Silver block technology is at the heart of the qTOWER³, offering outstanding homogeneity of only ±0.1°C over the entire 96-well block. Optionally, the linear gradient function is the optimal tool to easily adjust the instrument to different assays. The qTOWER³ is available either as a stand-alone device with an integrated 10-in. tablet or as a PC-based system. The software comes with a broad spectrum of optimized analysis algorithms, including absolute and relative quantification, melt point analysis, delta-delta cycle threshold (Ct) method, PCR efficiency, allelic discrimination, endpoint,

SPE Plates

The Strata-X µElution 96-Well Plates enable solid phase extraction (SPE) from samples as small as 10 µL, along with low elution volumes. These cost-effective 96-well plates conserve precious samples and reduce time requirements compared to traditional SPE plates, which require 200-µL elution volumes and a dry-down step to produce sufficient concentration. This dry-down step is time-consuming and can reduce analyte recovery of peptides and thermolabile compounds. The new Strata-X µElution 96-well plates are ideal for work with biological samples in pharmaceutical, clinical research, and forensic laboratories. Strata-X µElution 96-well plates follow the same procedure as traditional 96-well SPE plates, however elution volumes are as low as 25 µL, eliminating the need to perform a dry-down step. Strata-X µElution 96-well plates can be used with a vacuum manifold or positive-pressure system and can be automated with a robotic liquid handler for further time and labor savings.

Confocal Microscope

The HyVolution true confocal super-resolution technology for the Leica TCS SP8 confocal microscope platform allows researchers to resolve structures down to 140 nm with multiple colors, high imaging speed, and high signal-to-noise ratio. HyVolution can be ordered with every new Leica TCS SP8 and is also available as an upgrade to existing Leica TCS SP8 platforms. HyVolution is based on a combination of the unique Leica HyD hybrid detector, a workflow-oriented software wizard; best-in-class Huygens deconvolution software embedded via a direct interface in the Leica Application Suite X (LAS X) control software; and CUDA graphics processing unit-accelerated computing. Researchers benefit from HyVolution by imaging fast dynamic processes and capturing multiple colors simultaneously with the TCS SP8's spectral detection system, and can still achieve 140-nm resolution.

Cancer Stem Cell Identification Kit

The new AldeRed ALDH Detection Kit is designed for identifying and isolating cancer stem cells. The AldeRed reagent is used to label cancer stem cells with a red fluorescent dye, making it possible to distinguish cancer stem cells in live cell populations where specific identification was previously impossible. Aldehyde dehydrogenase (ALDH), a cancer stem cell marker enzyme, causes the AldeRed reagent to fluoresce in the far-red spectrum, allowing the cancer cells to be identified and isolated with concurrent use of green fluorescent cell lines, transgenic animals, and reporter assays. Previous ALDH reporters exhibited green fluorescence, which made it difficult to identify positive cells in an otherwise green fluorescent background.

Automated Materials Analyzer

The ABR Automated Breakthrough Analyzer is designed to meet the needs of researchers wishing to characterize the gas separation performance of novel materials, such as metal-organic frameworks (MOFs), zeolitic imidazolate frameworks (ZIFs), and covalent organic frameworks (COFs), without the time or expense of synthesizing larger quantities of material. Breakthrough curve measurement allows high-throughput screening and testing of adsorbents, for a wide range of separation processes including CO2 capture and storage, the purification and recovery of noble gases, natural gas and biogas upgrading, toxic gas removal, and air separation. The ABR is a dedicated breakthrough analyzer, fully automated and supplied with an integrated close-coupled quadrupole mass spectrometer. Different configurations are available to suit research-scale samples, with bed volumes from 2 cc to 20 cc. Up to six gas inlets are available as well as a dedicated purge stream. Flow rates are selected to suit the specific applications, and the ABR includes an ultralow dead-volume switching valve.

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  • Newly offered instrumentation, apparatus, and laboratory materials of interest to researchers in all disciplines in academic, industrial, and governmental organizations are featured in this space. Emphasis is given to purpose, chief characteristics, and availabilty of products and materials. Endorsement by Science or AAAS of any products or materials mentioned is not implied. Additional information may be obtained from the manufacturer or supplier.

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