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A long noncoding RNA associated with susceptibility to celiac disease

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Science  01 Apr 2016:
Vol. 352, Issue 6281, pp. 91-95
DOI: 10.1126/science.aad0467

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Long noncoding RNAs in inflammation

Growing evidence suggests that long noncoding RNAs (lncRNAs) are important modulators of gene expression. Castellanos-Rubio et al. identified a lncRNA, lnc13, that suppresses inflammatory gene expression in macrophages (see the Perspective by Huarte). Lnc13 interacts with proteins that regulate chromatin accessibility. Stimulating macrophages with a cell wall component from bacteria decreased expression of lnc13 and increased the expression of several inflammatory genes. Decreased levels of lnc13 in intestinal tissue from individuals with celiac disease hint that lnc13 may also play a role in the pathogenesis of immune-mediated diseases.

Science, this issue p. 91; see also p. 43