Research Article

Genetic circuit design automation

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Science  01 Apr 2016:
Vol. 352, Issue 6281, aac7341
DOI: 10.1126/science.aac7341

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Programming circuitry for synthetic biology

As synthetic biology techniques become more powerful, researchers are anticipating a future in which the design of biological circuits will be similar to the design of integrated circuits in electronics. Nielsen et al. describe what is essentially a programming language to design computational circuits in living cells. The circuits generated on plasmids expressed in Escherichia coli required careful insulation from their genetic context, but primarily functioned as specified. The circuits could, for example, regulate cellular functions in response to multiple environmental signals. Such a strategy can facilitate the development of more complex circuits by genetic engineering.

Science, this issue p. 10.1126/science.aac7341