Memory Research

A pathway for forgetting

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Science  15 Apr 2016:
Vol. 352, Issue 6283, pp. 305
DOI: 10.1126/science.352.6283.305-b

Memories tend to fade over time. We still only partially understand the processes that underlie this erosion of long-term memory. Migues et al. infused two synthetic peptides that slow down the activity-induced synaptic removal of a specific type of glutamate receptor into the rat dorsal hippocampus. This procedure prevented the forgetting of specific forms of spatial memory but did not block the acquisition of new object location memories. It also prevented the generalization of contextual fear. Infusion of one these peptides into a different brain area preserved extinction memory because it inhibited time-dependent spontaneous recovery of extinguished auditory fear.

J. Neuroscience 36, 3481 (2016).

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