Plant Science

Know when to hold 'em…

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Science  15 Apr 2016:
Vol. 352, Issue 6283, pp. 305-306
DOI: 10.1126/science.352.6283.305-g

During cell division, cohesins keep replicated sister chromatids attached until they segregate into separate daughter cells. This cohesion is stabilized by chromosome transmission fidelity 7 (Ctf7) protein and destabilized by the Wings apart-like (Wapl) protein. Inactivation of Ctf7 results in poorly condensed chromosomes, whereas inactivation of Wapl results in chromosomes that won't let go. De et al. investigated the interaction of cohesion, Wapl, and Ctf7 in Arabidopsis plants. Inactivation of Wapl is lethal to animal cells but has divergent effects on plant cells, so that meiosis and germ cell development are more affected than is vegetative plant growth. The results hint at an as-yet-unidentified system to regulate sister-chromatid cohesion during mitosis.

Plant Cell 28, 521–536 (2016).

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