Immunometabolism

A metabolic checkpoint for ILC2s

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Science  22 Apr 2016:
Vol. 352, Issue 6284, pp. 425-426
DOI: 10.1126/science.352.6284.425-e

Arginine metabolism regulates lung inflammation.

PHOTO: L. A. MONTICELLI ET AL., NATURE IMMUNOLOGY (4 APRIL 2016) © NATURE PUBLISHING GROUP

Infections are demanding, requiring immune cells to rapidly engage programs of gene expression and to alter their metabolism. Monticelli et al. provide insight into how one population of immune cells in the lung, termed type 2 innate lymphoid cells (ILC2s), modulates its metabolism in the face of lung inflammation or infection. They find that ILC2s express the enzyme arginase 1 (Arg1), which metabolizes L-arginine to generate urea and ornithine. Using mice lacking Arg1 specifically in ILC2s, they demonstrate that lung ILC2s require Arg1 for their proliferation and effector function in response to inflammation or infection. Disrupted amino acid metabolism and diminished glycolytic capacity probably account for the poor function of ILC2s in the absence of Arg1.

Nat. Immunol. 10.1038/ni.3421 (2016).

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