Science Webinar Series

Webinar | Metabolic regulation of immunity: Exploring programs that drive immune development and function

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Science  22 Apr 2016:
Vol. 352, Issue 6284, pp. 478
DOI: 10.1126/science.352.6284.478-b


According to conventional thinking, metabolic changes related to disease are thought to be triggered predominantly by signals from the immune cell-signaling network. However, recent evidence supports a role for metabolism as a “first responder” that can be decisive in actually forming immune responses and determining outcomes based on the metabolic potential and fitness of the responding cells. This new insight has led to the potential for reprogramming cellular metabolism to direct immune cell fate and function and thus to ultimately improve disease outcomes. In this webinar we will explain how metabolic pathways and substrates have been found to impact particular immune cell subsets and their functional roles. The application of this knowledge to better understand disease and to reveal novel therapeutic approaches will also be discussed.