PerspectiveCell Signaling

Liquidity in immune cell signaling

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Science  29 Apr 2016:
Vol. 352, Issue 6285, pp. 516-517
DOI: 10.1126/science.aaf8179

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Summary

Tlymphocytes of the immune system need to integrate myriad signals to decide on life and death matters in defending the host from pathogens and in distinguishing normal from transformed cells, all while minimizing immunopathology. On page 595 in this issue, Su et al. (1) provide insight into how phase separation of signaling proteins in the two-dimensional (2D) liquid of the plasma membrane enables these critical decisions.