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Population-based metagenomics analysis reveals markers for gut microbiome composition and diversity

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Science  29 Apr 2016:
Vol. 352, Issue 6285, pp. 565-569
DOI: 10.1126/science.aad3369

Article Information

vol. 352 no. 6285 565-569

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History: 
  • Received for publication September 1, 2015
  • Accepted for publication March 11, 2016

Author Information

  1. Alexandra Zhernakova1,2,*,
  2. Alexander Kurilshikov3,4,,
  3. Marc Jan Bonder1,,
  4. Ettje F. Tigchelaar1,2,,
  5. Melanie Schirmer5,6,
  6. Tommi Vatanen5,7,
  7. Zlatan Mujagic2,8,
  8. Arnau Vich Vila9,
  9. Gwen Falony10,11,
  10. Sara Vieira-Silva10,11,
  11. Jun Wang10,11,
  12. Floris Imhann9,
  13. Eelke Brandsma12,
  14. Soesma A. Jankipersadsing1,
  15. Marie Joossens10,11,13,
  16. Maria Carmen Cenit1,14,15,
  17. Patrick Deelen1,16,
  18. Morris A. Swertz1,16,
  19. LifeLines cohort study,
  20. Rinse K. Weersma9,
  21. Edith J. M. Feskens2,17,
  22. Mihai G. Netea18,
  23. Dirk Gevers5,,
  24. Daisy Jonkers8,
  25. Lude Franke1,
  26. Yurii S. Aulchenko4,19,20,21,
  27. Curtis Huttenhower5,6,
  28. Jeroen Raes10,11,13,
  29. Marten H. Hofker12,
  30. Ramnik J. Xavier5,22,23,24,
  31. Cisca Wijmenga1,*,§,
  32. Jingyuan Fu1,12,*,§
  1. 1University of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, Netherlands.
  2. 2Top Institute Food and Nutrition, Wageningen, Netherlands.
  3. 3Institute of Chemical Biology and Fundamental Medicine SB RAS, Novosibirsk, Russia.
  4. 4Novosibirsk State University, Novosibirsk, Russia.
  5. 5The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  6. 6Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
  7. 7Department of Computer Science, Aalto University School of Science, Espoo, Finland.
  8. 8Division of Gastroenterology-Hepatology, Department of Internal Medicine, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, Maastricht, Netherlands.
  9. 9University of Groningen, University Medical Center Groningen, Department of Gastroenterology and Hepatology, Groningen, Netherlands.
  10. 10KU Leuven–University of Leuven, Department of Microbiology and Immunology, Rega Institute for Medical Research, Laboratory of Molecular Bacteriology, Leuven, Belgium.
  11. 11VIB, Center for the Biology of Disease, Leuven, Belgium.
  12. 12University of Groningen, University Medical Center Groningen, Department of Pediatrics, Groningen, Netherlands.
  13. 13Vrije Universiteit Brussel, Faculty of Sciences and Bioengineering Sciences, Microbiology Unit, Brussels, Belgium.
  14. 14Microbial Ecology, Nutrition and Health Research Group, Institute of Agrochemistry and Food Technology, National Research Council (IATA-CSIC), Valencia, Spain.
  15. 15Department of Pediatrics, Dr. Peset University Hospital, Valencia, Spain.
  16. 16University of Groningen, University Medical Center Groningen, Genomics Coordination Center, Groningen, Netherlands.
  17. 17Division of Human Nutrition, Wageningen University, Wageningen, Netherlands.
  18. 18Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands.
  19. 19Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK.
  20. 20PolyOmica, Groningen, Netherlands.
  21. 21Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia.
  22. 22Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA, USA.
  23. 23Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Boston, MA, USA.
  24. 24Center for Microbiome Informatics and Therapeutics, Massachusetts Institute of Technology, Cambridge, MA, USA.
  1. *Corresponding author. Email: a.zhernakova{at}umcg.nl (A.Z.); c.wijmenga{at}umcg.nl (C.W.); j.fu{at}umcg.nl (J.F.)
  1. These authors contributed equally to this work.

  2. § These authors contributed equally to this work.

  • Present address: Janssen Human Microbiome Institute, Janssen Research and Development, Cambridge, MA, USA.

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