PerspectiveImmunology

A lipid arsenal to control inflammation

See allHide authors and affiliations

Science  03 Jun 2016:
Vol. 352, Issue 6290, pp. 1173-1174
DOI: 10.1126/science.aag0366

You are currently viewing the summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

Summary

Innate immune cells act as a surveillance system, detecting and responding to pathogens and endogenous danger signals. The complex patterns of signals they receive are detected by a variety of pattern recognition receptors (PRRs). On page 1232 of this issue, Zanoni et al. (1) find that innate immune responses to microbial products do not occur in a vacuum; rather, there is a complex array of danger signals in surrounding damaged tissue that can determine an immune cell type–specific response to pathogens. They describe a host-derived lipid that binds to a PRR to induce a hyperactive innate immune response that enhances long-lived protective immunity against invading microbes.