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Science  03 Jun 2016:
Vol. 352, Issue 6290, pp. 1238
DOI: 10.1126/science.352.6290.1238-a

Black Deep Well Plate

Porvair's new 96-well black deep well plate offers a working volume of 1 mL per well, which in conjunction with black sealing films, ensures that light sensitive assays and samples are not degraded by exposure to light, even over long-term storage periods. Manufactured from polypropylene, Porvair's black deep well microplate has excellent heat- and solvent-resistant qualities. Using only ultrapure grade polymers means that the black deep well plate has near-zero leachates, ensuring long-term sample integrity. The black plate is fully validated to be ribonuclease and deoxyribonuclease free, allowing it to be used with even the most sensitive biological samples. Benefiting from a cylindrical well design with round bottoms, the plate allows optimal mixing and easy sample recovery. Precisely manufactured to ANSI/SLAS dimensions, it is fully compatible with all commercially available microplate readers and automated liquid-handling equipment.

Next-Generation Sequencing Control

The Archer SureShot Triple (ALK, RET, ROS1) Fusion-Positive Control has recently been launched to benchmark greater confidence in gene fusion detection using Archer FusionPlex Panels. The reference control is comprised of formalin-fixed paraffin-embedded (FFPE) curls of homogenously mixed, precisely defined cell lines that contain EML4-ALK, CCDC6-RET, and SLC34A2-ROS1 fusions. When used alongside FusionPlex Panels that contain ALK, RET, or ROS1 fusions, the SureShot controls are a powerful measure of extraction, library preparation, sequencing, and panel performance. SureShot Negative Controls are also available, containing 100% wild-type cells that carry no target-gene fusion.

Genotyping Solution

The Eureka Genotyping Solution is a new, targeted genotyping-by-sequencing (GBS) solution that delivers high-throughput sample processing with low cost per sample. This result is enabled by an innovative, multiplexed combination of allele- and sample-specific barcodes that support high sample plexing on a sequencer while delivering high-quality single nucleotide polymorphism (SNP) analysis. The Eureka genotyping assay overcomes the challenges associated with current GBS technologies, which are susceptible to variability in genomic reads and missing SNP information, high cost, and complex informatics analysis. Customers can access the Eureka genotyping assay as a service provided by Affymetrix Research Services Laboratory or as a kit-based product to run in their own facility. Complementing the Eureka genotyping offerings, the new 24-sample configuration on the high-density Axiom 96 platform can interrogate upward of 800,000 markers, while the new 96-sample configuration on the Axiom 384 HT platform can assay about 50,000 genetic variants.

Vascular Contrast Agent

BriteVu offers the latest in terminal vascular contrast agents for use with advanced imaging such as micro-computed tomography (micro-CT). BriteVu fills the vascular system down to the capillary level, creating a detailed and highly visible cast. Important features include ease of use, low cost, high radiodensity, and safe ingredients. BriteVu has been successfully used in numerous mammal, reptile, and bird species—even human cadavers—to visualize the entire vascular system and specific organs or regions with incredible detail. Given its complete blood vessel filling, researchers can generate accurate 3D vascular maps for cancer, trauma, stroke, diabetes, malformations, and normal and other disease tissue states using CT. BriteVu can also be used in angiogenesis, drug development, and other studies.

GF-1 Viral Nucleic Acid Extraction Kit

The GF-1 Viral Nucleic Acid Extraction Kit is designed for rapid and efficient purification of viral DNA/RNA from samples such as serum, plasma, body fluid, or virus-infected cell culture supernatant. The purification is based on the usage of denaturing agents to provide efficient cell lysis, denaturation of proteins, and subsequent release of DNA or RNA. Special buffers provided in the kit are optimized to enhance the binding of DNA or RNA onto a specially treated glass filter membrane for efficient recovery of highly pure DNA or RNA. The kits require no organic-based extraction. They are highly pure DNA or RNA, ready to use for routine molecular biology applications such as PCR and reverse transcription PCR.

Gel Analysis Software

The new version of UltraQuant is a further step forward for this very user-friendly gel analysis software. Version 8.31.15 has a number of new and improved functions, making it one of the most convenient gel analysis packages available. UltraQuant is included with all Omega Lum systems, where it works seamlessly alongside the SmartCapture Technology imaging platform. Once an image is captured, UltraQuant can quickly and easily provide a full analysis of the gel or blot using a minimum of steps. Naturally, UltraQuant has a fully automatic mode for the detection of lanes and bands across the gel or blot. Detection sensitivity can be set to an optimum position to achieve the best result. A very effective and easy-to-use edit function gives the user complete control over any lane or band that needs to be added or subtracted.

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  • Newly offered instrumentation, apparatus, and laboratory materials of interest to researchers in all disciplines in academic, industrial, and governmental organizations are featured in this space. Emphasis is given to purpose, chief characteristics, and availabilty of products and materials. Endorsement by Science or AAAS of any products or materials mentioned is not implied. Additional information may be obtained from the manufacturer or supplier.

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