Aging

Longer life? It's all in the head

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Science  17 Jun 2016:
Vol. 352, Issue 6292, pp. 1422-1423
DOI: 10.1126/science.352.6292.1422-g

Caloric restriction extends life span and helps ward off diseases of aging in model organisms and may do so in primates as well. It's not pleasant, though, so a way to mimic its effect with a drug would be more appealing. Lucanic et al. screened for such a compound in the worm Caenorhabditis elegans and found one that extended life span in a manner similar to dietary restriction. Experiments to trace the point of action of the compound indicated that it may act by limiting activity in a neuronal pathway that senses the presence of food. Thus, sensory signaling pathways might be targets for agents that could mimic beneficial effects of dietary restriction on aging and health span.

Aging Cell. 10.1111/acel.12492 (2016).

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