Research Article

NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice

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Science  17 Jun 2016:
Vol. 352, Issue 6292, pp. 1436-1443
DOI: 10.1126/science.aaf2693

Article Information

vol. 352 no. 6292 1436-1443

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History: 
  • Received for publication January 16, 2016
  • Accepted for publication April 13, 2016

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Author Information

  1. Hongbo Zhang1,
  2. Dongryeol Ryu1,
  3. Yibo Wu2,
  4. Karim Gariani1,
  5. Xu Wang1,
  6. Peiling Luan1,
  7. Davide D’Amico1,
  8. Eduardo R. Ropelle1,3,
  9. Matthias P. Lutolf4,
  10. Ruedi Aebersold2,5,
  11. Kristina Schoonjans6,
  12. Keir J. Menzies1,7,*,
  13. Johan Auwerx1,*
  1. 1Laboratory of Integrative and Systems Physiology, École Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.
  2. 2Department of Biology, Institute of Molecular Systems Biology, Eidgenössische Technische Hochschule Zürich (ETHZ), 8093 Zurich, Switzerland.
  3. 3Laboratory of Molecular Biology of Exercise, School of Applied Science, University of Campinas, CEP 13484-350 Limeira, São Paulo, Brazil.
  4. 4Laboratory of Stem Cell Bioengineering, EPFL, 1015 Lausanne, Switzerland.
  5. 5Faculty of Science, University of Zurich, 8057 Zurich, Switzerland.
  6. 6Metabolic Signaling, EPFL, 1015 Lausanne, Switzerland.
  7. 7Interdisciplinary School of Health Sciences, University of Ottawa Brain and Mind Research Institute, 451 Smyth Road, K1H 8M5 Ottawa, Ontario, Canada.
  1. *Corresponding author. Email: kmenzies{at}uottawa.ca (K.J.M.); admin.auwerx{at}epfl.ch (J.A.)

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