DRUG DELIVERY

Drinking straws for the stomach

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Science  01 Jul 2016:
Vol. 353, Issue 6294, pp. 40
DOI: 10.1126/science.353.6294.40-b

Nanostraw membranes can provide prolonged and proximal drug release.

PHOTO: FOX ET AL., ACS NANO (7 JUY 2016) ACS PARAGON PLUS ENVIRONMENT

Systemic drug delivery to the gut by oral ingestion is simpler and more direct than routes such as an intravenous feed or an injection. However, barriers that line the stomach, high pH, enzymatic degradation, and limited residence time limit delivery. Fox et al. designed planar devices that are sealed with a membrane containing an array of stiff hollow tubes. Drugs are loaded by immersing the straws into a solution and allowing it to diffuse into the reservoir of the device. In vitro and ex vivo testing show that the straws enhance adhesion of the devices to the intestinal epithelium, while limiting the uptake of foreign molecules into the reservoir, and allow for tunable drug delivery when exposed to fluid flow.

ACS Nano 10.1021/acsnano.6b00809 (2016).

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