Cell Biology

Activating Inflammation

+ See all authors and affiliations

Science  01 Jul 2016:
Vol. 353, Issue 6294, pp. 40-41
DOI: 10.1126/science.353.6294.40-d

Calcium recruitment contributes to cell swelling and inflammation in wound healing.

PHOTO: ENYEDI ET AL.; CELL (19 MAY 2016) © 2016 CELL PRESS

Nuclear swelling recruits leukocytes, and cell swelling directly induces inflammation, but how cells convert changes in volume into inflammatory signals is unclear. Enyedi et al. combined quantitative imaging in live zebrafish and in cell culture and identified a mechanism by which both cell swelling and cell lysis stimulate the production of highly inflammatory lipid mediators. Swollen nuclei of permeabilized or swollen cells attracted leukocytes in vivo. Cell swelling induced nuclear swelling, which caused an enzyme in the inner nuclear membrane to release proinflammatory lipids. Restriction of nuclear swelling by actin filaments could limit this response. Thus, the nucleus plays an unexpected mechanosensory function to sense cell swelling and lysis and activate inflammatory signaling.

Cell 165, 1160 (2016).

Navigate This Article