Induction is the key to production

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Science  01 Jul 2016:
Vol. 353, Issue 6294, pp. 40-41
DOI: 10.1126/science.353.6294.40-f

The enzymatic conversion of lignocellulose to glucose is a bottleneck in the biological production of ethanol. Inducing the synthesis of active cellulytic enzymes is critical for enhancing the conversion efficiency of a bioreactor. Li et al. developed a method to stimulate the production of high amounts of cellulase in the fungus Trichoderma reesei. The most effective inducer was a sugar mixture synthesized from glucose, which contains sophorose. Batch feeding of the mixture resulted in high cellulase production at levels three to five times higher than previously measured. Adding pretreated corn stover to the reactor resulted in high yields of glucose and of conversion to ethanol.

Bioresour. Technol. 216, 503 (2016).

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