CANCER GENOMICS

Immune differences in colorectal cancers

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Science  29 Jul 2016:
Vol. 353, Issue 6298, pp. 459-460
DOI: 10.1126/science.353.6298.459-b

Synchronous colorectal cancers (SCCs) occur when more than one malignant lesion is present within the colon at a time. Cereda et al. exome-sequenced paired tumors and matched normal samples across 10 patients with SCCs. High tumor heterogenity was observed, suggesting independent underlying genetic origins of tumors in at least 7 of the 10 patients examined. Comparisons of multiple-tumor patients with individuals who had only a single colorectal tumor revealed germline (nontumor) enrichment of mutations in immune-related genes, as well as different immune cell composition in the normal colonic mucosa and higher tumor-associated inflammation. These data suggest that impaired immune processes may be a factor in SCCs.

Nat. Comm. 10.1038/ncomms12072 (2016).

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