Infectious Diseases

How antibiotic resistance spreads

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Science  05 Aug 2016:
Vol. 353, Issue 6299, pp. 554
DOI: 10.1126/science.353.6299.554-a

Resistance of Shigella bacteria to antibiotics is a growing problem.


Shigella bacteria cause diarrheal illnesses in about 125 million people each year, particularly in developing countries. Antibiotics are widely used to prevent complications and reduce spreading of the disease, but resistance to the antibiotic ciprofloxacin is an increasing problem. The et al. report whole-genome sequencing of 60 ciprofloxacin-resistant S. sonnei bacteria from Vietnam, Bhutan, Thailand, Cambodia, Australia, and Ireland. They show that the bacteria all belong to the same lineage, one that probably originated in South Asia. This lineage emerged in a single clonal event and has since spread widely across Asia and beyond.

PLOS Med. 10.1371/journal.pmed.1002055 (2016).

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