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Science  05 Aug 2016:
Vol. 353, Issue 6299, pp. 610
DOI: 10.1126/science.353.6299.610

Cell Culture System

The Avatar system enables a new generation of cell-based assays by allowing for complete control of key physiological conditions found in cell microenvironments, including settings for pressure, oxygen, temperature, and carbon dioxide levels. Mimicking the physiological conditions of a sample's native environment is critical to obtaining accurate and actionable experimental results in important fields such as cancer research, biomarker discovery, lead candidate selection and optimization, stem cell research and regenerative medicine, and immunotherapy drug development. Avatar provides a new platform for culturing and propagating tumor samples, circulating tumor cells from liquid biopsies, stem cells, and primary samples. In addition to enabling the culturing of difficult samples such as tumor biopsies and primary samples, the system overcomes the limitations of traditional cell cultures to generate results that exhibit the phenotypic, genomic, and proteomic characteristics of the native sample.

CHO Cell Media

BalanCD CHO Feed 4 is a chemically defined, animal component-free powder feed for large-scale bioproduction in a variety of high-performing Chinese hamster ovary (CHO) cells. When paired with BalanCD CHO Growth A in fed-batch culture systems, BalanCD CHO Feed 4 can achieve cell density of up to 20 million viable cells/mL and antibody titers of up to 6 g/L. Recent developments in cell-line engineering have resulted in cell lines capable of reaching high cell densities and productivity rates. To achieve their full production potential, these cell lines need nutrient-rich media; however, these feeds can be difficult to dissolve and require complicated, time-consuming preparation protocols. BalanCD CHO Feed 4 is designed and formulated to prepare easily using a simplified hydration procedure that does not require pH adjustments. It maintains pH stability in culture and is designed to support growth while minimizing the production of metabolites that adversely affect titer levels, resulting in process consistency and high protein production and protein quality.

Flow Slides and Channels

The µ-Slide Membrane ibiPore Flow—a product designed for migration and transport studies on cells—enables researchers to culture single or multiple cell types on a porous glass membrane, and then analyze the cells using high-resolution microscopy—something that is not currently possible when using typical polymer cell-culture inserts. This special microscopy chamber contains a cross-channel structure with a thin, porous, optical glass membrane located in between. Cells can be cultured on both sides of the glass membrane and then visualized using phase contrast or fluorescence microscopy. The special construction of the slide allows full fluidic access to the apical and basal sides of adherent cells for cell studies under static or flow conditions. Typical applications include coculture of smooth muscle cells with endothelial cells under perfusion, transmigration of leukocytes with dynamic shear stress, and invasion assays using cancer cells.

Kinetic Cytometry Imaging

Livecyte enables cell biology researchers to achieve a deeper understanding of the phenotypic and kinetic behaviors of both individual live cells and live-cell populations in a label-free environment, and uniquely allows users to interleave fluorescence measurements during different drug treatments or across cell types within a single experiment. With the ability to image multiple regions of interest within wells and across well plates, this intuitive system delivers multiparametric, quantitative data and high-contrast, high-fidelity images and videos. Perfectly focused cells and powerful cell-tracking software (patent pending) enable enhanced lineage tracking. The system's ability to image continuously ensures that large (mm) fields of view can be captured without stitching, so highly motile cells are not lost during long time courses. Cell perturbation is minimized because cells are imaged in their growth media. This technique is particularly useful for fragile cells such as primary cells and stem cells.

Automated Cell Counter

The Countstar Automated Cell Counter is a cell-counting and analysis instrument based on the classic trypan blue staining method. The system integrates advanced optical imaging technology with intelligent image recognition technology to give outstanding results. At its heart is a powerful software system that integrates basic cell counting and cell morphology analysis with analysis charts and data management capabilities. The Countstar offers accurate and rapid counting, innovative cell aggregation correction, and rigorous manual impurity correction. One-stop statistical analysis capability combined with flexible data output and advanced data security features make the Countstar one of the most advanced systems of its type on the market. The Countstar IC1000 measures not only cell concentration and viability, but also gives the average diameter range and aggregation of cells in the form of histograms.

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  • Newly offered instrumentation, apparatus, and laboratory materials of interest to researchers in all disciplines in academic, industrial, and governmental organizations are featured in this space. Emphasis is given to purpose, chief characteristics, and availabilty of products and materials. Endorsement by Science or AAAS of any products or materials mentioned is not implied. Additional information may be obtained from the manufacturer or supplier.

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