Vaccine Development

Single serotype for Zika

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Science  19 Aug 2016:
Vol. 353, Issue 6301, pp. 787-788
DOI: 10.1126/science.353.6301.787-b

Zika virus strains are of either African or Asian genetic lineage, and Asian strains are the cause of the outbreak in Central and South America. Dowd et al. report that natural antibodies produced by individuals infected with the presently circulating Asian strains can neutralize viruses from either lineage. This indicates a single Zika viral serotype and suggests that a single-strain vaccine could be broadly protective against diverse strains of Zika. Antibodies elicited by Zika virus target the envelope protein of the virion, for which the two genetic lineages share >95% amino acid identity.

Cell Rep. 10.1016/j.celrep. 2016.07.049 (2016).

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