Host Responses

Inflammation blocks recovery

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Science  09 Sep 2016:
Vol. 353, Issue 6304, pp. 1110-1111
DOI: 10.1126/science.353.6304.1110-d

Although antibiotics can clear the pathogen, doctors typically do not prescribe them to treat nontyphoidal Salmonella infections, which are a major cause of gastroenteritis worldwide. This is because antibiotics actually extend the course of disease. Now, Dolowschiak et al. provide some insight into why. Using a mouse model of Salmonella infection treated with ciprofloxacin, they found that the cytokine interferong-γ(IFNγ) promotes intestinal pathology even after the majority of the bacteria are cleared. T cells and natural killer cells make IFNγ, which drives proinflammatory myeloid cells to accumulate, spewing forth pathology-causing soluble mediators that prevent tissue repair. Targeting this pathway therapeutically may help alleviate the debilitating symptoms that Salmonella can cause.

Cell Host Microbe 20, 238 (2016).

Nontyphoidal Salmonella infections are not typically treated with antibiotics.

PHOTO: MICHAEL ABBEY/SCIENCE SOURCE

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