Aging

Regeneration of NAD keeps mouse muscles young

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Science  16 Sep 2016:
Vol. 353, Issue 6305, pp. 1246-1247
DOI: 10.1126/science.353.6305.1246-f

Evidence for a critical role of nicotinamide adenine dinucleotide (NAD) metabolism in aging is accumulating. Frederick et al. studied mice with muscle-specific depletion of nicotinamide phosphoribosyltransferase (Nampt), an enzyme needed to restore concentrations of NAD in working muscle. Muscle in young animals tolerated a large reduction in the amount of NAD without obvious loss of function. However, older control animals had decreased muscle concentrations of NAD, which correlated with decreased performance, and these effects were more pronounced in animals lacking Nampt. Restoration of NAD concentrations by feeding older animals nicotinamide riboside partially restored muscle function. Accordingly, overexpression of Nampt in muscle helped prevent the age-dependent decline in muscular function. Thus, maintenance of proper NAD metabolism in muscle appears to be needed for sustained function.

Cell Metab. 10.1016/j.cmet.2016.07.005 (2016).

Correction (3 October 2016): This Week in Other Journals, "Regeneration of NAD keeps mouse muscles young" (16 September 2016, p. 1247). An error was introduced during the production process. The definition of the acronym NAD should be nicotinamide adenine dinucleotide. The HTML and PDF have been corrected.

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