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Science  23 Sep 2016:
Vol. 353, Issue 6306, pp. 1449
DOI: 10.1126/science.353.6306.1449-a

Bead Mill

A new, compact, and robust horizontal bead mill system provides versatility for a wide range of laboratory dispersion tasks. Dispermat SL-B is for fine-grinding batch sizes from 150 mL to 750 mL. It features an integrated mill- base circulation system and a speed control that adjusts from 0 rpm to 6,000 rpm. The mill base is pressed out to ensure that the dispersed product can be almost completely regained with minimal wastage. Product samples are conveyed through the horizontal milling chamber by a spiral conveyor, while the separation of the mill base is made by a dynamic gap. Dispermat SL-B features a wear-resistant, stainless-steel milling chamber and a milling rotor made of hardened nitride steel. Shaft sealing is provided by a mechanical seal with integrated pressure system and cooling. The speed and timer controls are contained in separate stainless-steel housing with an easy-to-read digital display. An explosion-proof ATEX-approved version is also available.

Human Genomic Reference Samples

iPLEX reference standards are now available for performance verification of oncology assays used on the MassARRAY System. The standards contain somatic variants in key oncogenic genes implicated in colon, lung, and skin cancers. Made from genetically engineered cell lines, these standards will be provided at fixed and known allelic frequencies, thereby mimicking real patient tumors. The MassARRAY System enables rapid assay development for targeted and highly sensitive mutation analysis. Tens to hundreds of actionable genetic variants are easily tested. The system is used globally in diverse research fields such as cancer profiling for solid tumor and liquid biopsies, inherited genetic disease testing, pharmacogenetics, agricultural genomics, and clinical research. However, robust assay performance requires up-front analytical verification and validation. These standards will be a valuable resource for laboratories to speed analytical validation and will serve as ongoing positive controls, complementing laboratories' evaluation of clinical research specimens.

Immunoassays

Matched recombinant, monoclonal antibody pair kits provide assays with reproducible, sensitive, and high-throughput detection. Matched antibody pairs are central to enzyme-linked immunoabsorbent assays (ELISAs), which are widely used to study secreted biomarkers and are fundamental to research in areas such as immunology and cancer. Using patented recombinant monoclonal antibody technology such as RabMab, the pairs avert the reproducibility and scalability challenges previously faced by researchers, which cause variability in results. The pairs are screened for sensitive performance and rigorously tested in a variety of complex sample types including plasma, serum, and cell lysates. These optimized pairs are already part of Abcam's SimpleStep ELISA kits, and will now be available as stand-alone matched antibody pair kits. The new stand-alone, high-volume format provides greater flexibility to researchers and facilitates cost-effective drug discovery by enabling scale-up from small pilot studies to large-scale, high-throughput assay platforms.

Arc Process Sensors

ArcAir enables reliable, economical Bluetooth 4.0 wireless connectivity in all environments. The new Bluetooth capability allows users to view or control Hamilton Arc sensors from numerous devices, including smartphones and tablets. ArcAir apps are available for both Android and iOS platforms in three versions: ArcAir Lite (free), ArcAir Basic, and ArcAir Advanced. Arc sensor technology has a built-in microprocessor that provides direct digital and analog communication and eliminates the need for separate transmitters. Arc sensors have improved process measurement accuracy and speed while reducing installation and maintenance costs. The ArcAir mobile application for pH, dissolved oxygen, and conductivity measurements can communicate wirelessly with up to 30 individual sensors at the same time. Hamilton also offers a Bluetooth version of its GMP Compliance Package software, which works with ArcAir Advanced and provides centralized management of users and validation reports for calibration, veri-fication, configuration, and communication.

Pathology Image Analysis Software

Established as the industry's fastest and most user-friendly analysis platform for digital pathology images, HALO 2.0 adds new capabilities and support for file formats. HALO 2.0 sports a more modern look and feel, including interchangeable skins to ease eyestrain when working with darkfield and brightfield images. It also adds a new tuning interface to facilitate analysis; the ability to create spatial plots, heat maps, and histograms from any HALO analysis result; and tools for data import/export, sharing, archiving, and report generation. For immuno-oncology and angiogenesis researchers, the spatial analysis module is a suite of tools for analyzing proximity and relative spatial distribution of objects, cells, and/or features across single tissues or serial sections. The high-plex FL module can simultaneously analyze up to eight markers and can be used with most fluorescent whole-slide image formats, including multispectral floating-point .qptiff images and whole-slide images produced from the Perkin-Elmer Vectra 3 platform.

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  • Newly offered instrumentation, apparatus, and laboratory materials of interest to researchers in all disciplines in academic, industrial, and governmental organizations are featured in this space. Emphasis is given to purpose, chief characteristics, and availabilty of products and materials. Endorsement by Science or AAAS of any products or materials mentioned is not implied. Additional information may be obtained from the manufacturer or supplier.

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