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Chromatin untangled: New methods map genomic structure

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Science  07 Oct 2016:
Vol. 354, Issue 6308, pp. 118-120
DOI: 10.1126/science.354.6308.118


With some 2 meters of DNA squished into the micron-sized nucleus of every mammalian cell, to call that space "cozy" is an understatement. Yet for cells, the genome poses issues not only of compaction but of functionality: The DNA must be packaged such that it remains accessible to gene regulatory factors. Indeed, chromatin architecture plays a key role in gene regulation, but until recently, researchers had few tools with which to study that relationship.