Editors' ChoiceT Cell Memory

Priming for T cell memory in tissues

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Science  21 Oct 2016:
Vol. 354, Issue 6310, pp. 298
DOI: 10.1126/science.354.6310.298-b

During infections, dendritic cells prime T cell immunity and drive a subset of T cells to become long-lived memory cells. Memory T cells come in two flavors: those that circulate and those that establish long-term residency in tissues (Trm). Iborra et al. investigated the priming requirements of each type of cell in mice. Direct antigen presentation by dendritic cells is sufficient for generating circulating memory CD8+ T cells. In contrast, CD8+ Trm cells require antigen cross-presentation by dendritic cells that express DNGR-1, a protein receptor that binds necrotic cells. Without either DNGR-1 or cross-presenting dendritic cells, mice form few Trm cells in response to viral infection.

Immunity 10.1016/j.immuni.2016.08.019 (2016).

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