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Science  21 Oct 2016:
Vol. 354, Issue 6310, pp. 373
DOI: 10.1126/science.354.6310.373-a

Magnetic Bead Extraction Platform

EXTRACTMAN is a biomolecule extraction platform enabling researchers to better study complex protein interactions that are critical for drug target identification, as well as numerous topics in proteomics research. The platform can isolate weak interactors and transiently bound complexes that traditional isolation techniques leave behind. These weak interactors represent potentially unseen targets that are integral to fully understanding protein functions, molecular mechanisms, posttranslational modifications, and cell-signaling cascades. Protein isolation using EXTRACTMAN can be performed in significantly less time compared to more traditional tube-based magnetic bead procedures, with up to four samples isolated in parallel in as little as 30 seconds. The platform is ideal for capturing weakly bound protein–protein and cell–protein complexes, because they are not exposed to the high shear forces generated by multiple pipet-based wash steps and require less time in prodissociating wash buffers. EXTRACTMAN uses many commercially available paramagnetic beads, making it easy to adapt existing protocols.

siRNA-Validated Antibodies

Proteintech is accelerating its small interfering RNA (siRNA) knockdown program to ensure each one of its 12,000+ antibodies meets rigorous validation standards. siRNA knockdown verifies accurate validation as a negative control to confirm that the antibody binds only to the target protein. These Western blots are performed on whole-cell lysates in which siRNA knocks down expression of the target protein. The original antibody manufacturer became the first company to implement this method in 2014, and continues to push for industry-wide transparency and reproducibility by publishing all of its validation data online. From start to finish, every antibody is made in-house. Proteintech also recently launched its Antibody Upgrade Program, which allows scientists to locate Proteintech equivalents for discontinued or out-of-stock products from all major antibody suppliers.

Size-Exclusion Chromatography Columns

Superdex 75 Increase is a size-exclusion chromatography resin for fast, reproducible, and high-resolution small-scale purification and analysis of recombinant tagged proteins. Compared with predecessor products, these prepacked columns offer runtimes reduced to one-third with maintained resolution. They are for use with proteins with molecular weights ranging from 3,000 to 70,000, for a variety of applications including preparative protein purification (µg to mg quantities), aggregate analysis, complex formation studies, and sample screening. The 10 × 300 mm column is well suited for high-resolution separations for both preparative and analytical purposes, with 25 µL–500 µL sample volumes. For smaller sample volumes (4 µL–50 µL) and high-resolution preparations and analyses, the 3.2 × 300 mm column is the best choice. The shorter 5 × 150 mm column is suitable for quick purity checks and rapid screening when the highest resolution is not needed.

Chemiluminescent Substrate

Thermo Scientific SuperSignal West Pico PLUS Chemiluminescent Substrate is the newest addition to the SuperSignal product line. Chemiluminescence is the Western blot detection method of choice in many protein laboratories, as it provides high sensitivity and convenience for detection with film or digital imaging equipment. The new formulation allows for brighter, more intense bands that display strong signal stability over the critical time period, allowing for the acquisition of multiple exposures. The high intensity of the light emission is coupled with excellent sensitivity—from the picogram down to the femtogram level—making it easy to obtain publication-quality blot images. SuperSignal West Pico PLUS is used for the detection of horseradish peroxidase and is compatible with different membranes and blocking reagents. It works over a wide range of antibody dilutions and across many different targets, making it an ideal choice for most Western blotting applications.

UV-Blue Light Converter Screens

Syngene's UV-Blue Light Converter Screens offer a safe, affordable way of using the UV transilluminator in Syngene imaging systems to visualize DNA and protein gels labeled with many commercial fluorescent dyes. The screens come in two sizes (21 cm × 26 cm and 25 cm × 30 cm) and are made of scratch- resistant plastic. Instead of purchasing a new imager or blue light box, researchers can inexpensively convert the transilluminator in their Syngene G:BOX, U:Genius3, InGenius3, and NuGenius systems into a blue-light powerhouse. The screen will alter the 302-nm UV wavelength to 460 nm–470 nm, preventing damage to scientists' skin and eyes while they are visualizing their gels. This adjusted wavelength is optimum for viewing a wide variety of fluorescent colors and gels stained with sensitive dyes, including GelRed, GelGreen, SYBR Safe, SYBR Gold, SYBR Green, SYPRO Ruby, SYPRO Orange, and Coomassie Fluor Orange.

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