Contents

04 November 2016
Vol 354, Issue 6312

About The Cover

Cover image expansion

COVER A woman holds her hand in ice water, one of several techniques used to measure pain tolerance. Typically, healthy people can submerge their hands for up to 5 minutes. However, for some of those taking opioids, 10 to 15 seconds is the limit, suggesting opioid-induced hypersensitivity to pain. For more on recent developments in pain research, see the special section beginning on page 564
Photo: Matthew Rakola